Exflagellation of malarial parasites in human peripheral blood.

Malaria exflagellation in a human peripheral blood smear

A clinical case is presented here of a patient from Afganistan. We found intraerythrocytic parasites consistent with malaria vivax. Additionally extraerythrocytic structures were seen. First a co-infection with Borrelia recurrentis was discussed later these structures were identified as male plasmodia microgametes resulting from exflagellation.

First Report of Neutrophil Involvement of Exflagellated Plasmodium vivax Microgametes

Dear editor Malarial infections pass through multiple stages, beginning in the hepatic parenchymal cells where invading sporozoites mature into schizonts. On maturation, these schizonts rupture and release merozoites into the bloodstream, which, in turn, target erythrocytes, leading to the clinical manifestations of the disease [1]. Exflagellation is characterized by thin, flagella-shaped micro...

A Preliminary Report on the Minimum Curative Dose of Quinine in the Treatment of Malarial Fever by the Intravenous Method

a day during the second month, then 5 grains twice a day during the third month." In the trea'ment of malarial fever by the intravenous injection of quinine, a method which one sometimes adopts in cases suffering from recurring attacks, the physician has to decide when there has been complete sterilization of the system. Negative results on examination of the peripheral blood are of no help wha...

Maintenance of the human malarial parasite, Plasmodium falciparum, in scid mice and transmission of gametocytes to mosquitoes

The study of human malaria has been hampered by the lack of small animal models for the human-infecting malarial parasites. To approach this problem, the erythrocytic stages of the human malarial parasite Plasmodium falciparum were adapted to in vitro growth in the presence of ascites fluid from mice homozygous for the severe-combined immunodeficiency (scid) mutation. Human red blood cells (hRB...

Transmission Dynamics of Malaria in Human Host: a Neuro-Fuzzy Approach